What is O-negative blood and why is it so important? (2024)

Fewer than one in ten people in Canada have O-negative blood, and their donations are crucial in emergencies

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February 10, 2023

What is O-negative blood and why is it so important? (1)

A trauma patient arrives at the emergency room. The medical team doesn't know her blood type or if she has any special blood requirements, and it will take at least 45 minutes to find out. But she doesn’t have that much time. She’s bleeding too much.

Thankfully, she can rely on the generosity of O-negative blood donors to keep her alive when every moment matters.

O-negative blood donors, sometimes called “universal blood donors,” are essential to saving the lives of patients whose blood type is unknown.

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“Every time a person is in a trauma or losing a lot of blood, we’re going to use O-negative blood till we know their blood type,” says Dr. Jeannie Callum, transfusion medicine specialist and hematologist at Kingston Health Sciences Centre and professor in the Department of Pathology and Molecular Medicine at Queen’s University.

“We will switch when we know it’s safe, but it takes about an hour to find out and that window is critical.”

Only 12 per cent of Canadian Blood Services donors are O-negative which means our inventory is frequently in short supply while demand is always high.

What is O-negative blood?

A person’s blood type is determined by protein and sugar molecules on their red blood cells.

“Our red blood cells have 360 protein and sugar decorations on their surfaces, called antigens, and among those 360 there are two really important antigens: ABO and Rhesus,” explains Dr. Callum.

The ABO systemis composed of A and B antigens. If your blood has just one of the two, you’ll be type A or B, depending which antigen you have. Some people have both antigens, so their blood type is AB. If you have neither antigen, you’re type O.

The other most important system, the Rhesus or Rh system, involves a protein called the D antigen. If your red blood cells have the D antigen, you have a positive blood type. If they don’t, your blood type is negative.

What is O-negative blood and why is it so important? (2)

How many people in Canada have O-negative blood?

Countries vary in terms of which blood types are most common. But in Canada, fewer than one in ten people have O-negative blood.

Blood type is inherited. So if you have a biological parent or sibling with O-negative blood, you might be O-negative as well. But you could have O-negative blood even if your parents have blood types A or B. When you donate blood for the first time, we’ll test and confirm your ABO type at every donation.

What is O-negative blood and why is it so important? (3)

Did you know...

…that originally, all humans had A-positive blood? However, for complex reasons, having type O blood reduces the chance of death from malaria. So over many millennia, evolution has driven a gradual increase in the number of people with type O blood. Find out if you have type O blood by booking an appointment.

Why blood type matters

Our immune systems are designed to know what belongs in our body and what doesn’t. When recipients get blood containing antigens that don’t occur in their own blood, things can go very wrong.

“If you don’t have an antigen and someone puts blood containing that antigen into you, your immune system goes into attack mode and blows up those transfused blood cells,” says Dr. Callum.

“Your kidneys are likely to go into failure, you get really sick, and many patients in that situation will die."

Thanks to the availability of type-O blood and modern testing protocols, the above scenario is very unlikely to occur. In fact, the risk of ABO incompatible transfusion is estimated to be 1 in 354,000.

The D antigen is also very important because if a person with child-bearing potential is Rh-negative and receives Rh-positive blood, they will likely develop an antibody that could cause future pregnancy complications and losses.

What is O-negative blood and why is it so important? (4)

O-negative blood is necessary for emergencies

In short, O-negative blood is critical because of what it doesn’t have: the A, B and D antigens, which can all trigger an immune response when the recipient isn’t a match. That’s why donations from people with O-negative blood can help people with any other blood type, and why O-negative blood is vitally importantto emergency and critical patient care.

It’s also why Dr. Callum, who has O-negative blood herself, has made donating blood a priority.

“It’s a little magical to donate blood and know that about a week later your blood is in a patient somewhere and helping them feel better,” she says. “I feel it’s my duty to donate while I’m healthy and able. Especially because I know a lot of O-negative blood is used for emergency resuscitation and newborn babies.”

Note: an earlier version of this article was published in August 2021.

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What is O-negative blood and why is it so important? (2024)

FAQs

What is O-negative blood and why is it so important? ›

O negative is the most common blood type used for transfusions when the blood type is unknown. This is why it is used most often in cases of trauma, emergency, surgery and any situation where blood type is unknown. O negative is the universal blood type.

Why is O-negative blood so important? ›

O negative donors are often called 'universal donors' because anyone can receive the red blood cells from their donations. Although about 8% of the population has O negative blood, it accounts for around 13% of hospital requests for red blood cells.

What is the disadvantage of o-negative blood group? ›

Individuals of the O-negative blood group suffer from inflammation from foods such as dairy products and wheat. This causes an imbalance in the person's immune system and is responsible for weight gain. Overactive immunity increases the risk of thyroid disease in type O-negative blood.

What are the benefits of having O blood? ›

Of the eight main blood types, people with Type O have the lowest risk for heart attacks and blood clots in the legs and lungs. This may be because people with other blood types have higher levels of certain clotting factors, which are proteins that cause blood to coagulate (solidify).

What are the benefits of having a negative blood type? ›

Why is A negative blood important? A negative red blood cells can be used to treat around 40% of the population. However, A negative platelets are particularly important because they can be given to people from all blood groups. That's why A negative platelets are called the 'universal platelet type'.

What kind of blood makes you a universal recipient? ›

Universal Recipient Blood Type

Blood donors with type AB+ (AB positive) are referred to as universal recipients and can receive red blood cells from any other blood type.

What is the personality of a person with O blood type? ›

Blood type O: People with O blood type are often considered outgoing, optimistic, and daring. They are seen as natural leaders with high standards for themselves. While they are generally confident and resilient, they can easily be perceived as jealous, insensitive, or arrogant.

Which blood group has the highest IQ? ›

In 2014, a study conducted in Jordan found significant associa- tion between blood group and intelligence with the highest IQ levels reported among individuals with 'AB' blood type [13].

Do O negative blood types live longer? ›

Chances are higher you'll live longer if you have type O blood. Experts think your lowered risk of disease in your heart and blood vessels (cardiovascular disease) may be one reason for this.

What is so rare about O negative blood? ›

Only 7% of the population have O negative blood. Due to the its versatility for transfusions, it is in high demand. In an emergency, it is the blood product of choice. For example, just one car accident victim can require up to 100 units of O neg.

What makes O blood unique? ›

Unlike the other key blood types, O negative is missing all highly reactive antigens – that's why it's called 'O negative'. The letter 'O' indicates an absence of A and B antigens, while 'negative' indicates the absence of the Rh factor (RhD). Without these, there's nothing to alert the recipient's immune system.

Does blood type O protect against Covid? ›

Bloomberg Several studies have now shown that people with blood type O are less susceptible to contracting Covid, and those with blood type A are more likely to get it. In the early days of the pandemic, those findings were hotly debated.

Who should not donate blood? ›

Some Conditions That Disqualify People From Donating Blood
ConditionPermanent or Temporary Disqualification
Cancers involving blood cells (for example, leukemia, lymphoma, or myeloma)Permanent
Cancers, otherTemporary
Temporary
Heart disease, severePermanent
17 more rows

What is the best blood type to have and why? ›

Why? O negative blood can be used in transfusions for any blood type. Type O is routinely in short supply and in high demand by hospitals – both because it is the most common blood type and because type O negative blood is the universal blood type needed for emergency transfusions and for immune deficient infants.

How did I get a negative blood type? ›

Each person has two Rh factors in their genetics, one from each parent. The only way for someone to have a negative blood type is for both parents to have at least one negative factor. For example, if someone's Rh factors are both positive, it is not possible for his or her child to have a negative blood type.

What foods should blood group A negative avoid? ›

The diet for A blood types recommends people avoid consuming most animal meat products and certain seafood, such as:
  • beef.
  • pork.
  • lamb.
  • veal.
  • venison.
  • duck and goose.
  • anchovy.
  • barracuda.

Why O negative is the rarest blood group? ›

Only 7% of the population are O negative. However, the need for O negative blood is the highest because it is used most often during emergencies. The need for O+ is high because it is the most frequently occurring blood type (37% of the population). The universal red cell donor has Type O negative blood.

What should blood type O negative people eat? ›

Diets for Group O Blood Type

Eat lots of meat. Your digestive system can handle red meat well. Eat seafood on a regular basis to help your thyroid. Keep the levels of dairy products (milk and cheese) and eggs in the moderate level to prevent lipids and cholesterol build up.

Can your blood type change from O negative to positive? ›

Usually, you'll have the same blood type all of your life. In rare cases, however, blood types can change. The change usually relates to unique circ*mstances, such as having a bone marrow transplant or getting certain types of leukemia or infections. Not all of these changes in blood type are permanent.

What blood type rejects pregnancy? ›

If the mother is Rh-negative, her immune system treats Rh-positive fetal cells as if they were a foreign substance. The mother's body makes antibodies against the fetal blood cells. These antibodies may cross back through the placenta into the developing baby. They destroy the baby's circulating red blood cells.

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